Overview

this combination is used to treat various disorders such as hypocalcemia , osteomalacia and rickets, tetany .

Indications

• Hypoparathyroidism
• Osteomalacia
• Rickets
• Osteoporosis

About Composition

Calcium Citrate:

Increases plasma calcium levels leading to increase in calcium deposition into bone. Calcium affects parathyroid cells by stimulating a G-protein coupled calcium receptor present on the surface. The reduction in calcium excretion increases the amount of calcium deposited in bone resulting in an increase in bone mineral density.

Vitamin D3:

Calcitriol is an active metabolite of vitamin D. calcitriol is also known as vitamin d3.Calcitriol plays an essential role in regulating plasma calcium in concert with parathyroid hormone (PTH) by increasing absorption of dietary calcium through and phosphate from the gastrointestinal tract, preventing renal tubular secretion of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system.  In addition to promoting fatty acid synthesis and inhibiting lipolysis, calcitriol is mainly used as a medication in the treatment of secondary hyperparathyroidism and resultant metabolic bone disease, hypocalcemia in patients undergoing chronic renal dialysis, and osteoporosis.

Folic acid:

folic acid is the important cofactor in the DNA and RNA synthesis. folic acid helps to run the body machinery and for the production and maintenance of new cells . It is used to treat folic acid deficiency anemia and other forms of anemia . Folic acid is the main precursor for the synthesis of tetrahydrofolic acid .

Mechanism of action

Folic acid is converted into active form i.e tetrahydrofolic acid and methyltetrahydrofolate with the help of dihydrofolate reductase then they are transported across the cells through endocytosis and mediate the synthesis of purines and pyrimidines .

Side Effects

• Nausea
• Vomiting
• Increased urine
• Constipation
• Myopathy
• Fatigue

Contraindication

• People who have high calcium and phosphate level in the blood .
• In kidney stones.